

They are seen aiding Jen, the Postal Dude, and Sergey Mavrodi in a mission to confront the Hockey Moms/ Nerds that have taken over Thompson's Funland Arcade. Their leader is revealed to be Jennifer Walcott, who is promoting a "Postal Babes Gone Insane" DVD line. They are armed with Shotguns or Machine Guns and behave similarly to the RWS Staff, having very high health and acting as allies of the Postal Dude if a firefight breaks out near them. Postal Babes appear throughout Paradise in Paradise Lost. The Postal Dude asks Vince to save a blonde for him. After the Dude defeats Phraud Hogslop, Vince Desi invites the him to a party at his house with the Postal Babes.

In Apocalypse Weekend, Postal Babes appear in a dream of the Postal Dude while he was unconscious at the Hospital. The Postal Babes are the main focus of the "Snatch" mode, in which is the standard "Capture the Flag" except it's a babe instead of a flag. They appear out of smoke to cheer the winner/team, making sexual moaning noises while music plays. The Postal Babes make their first appearance In the Share The Pain.
